Acetaminophen toxicity up-regulates MRP2 expression in the liver of cats: an old story with new vision |
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| Authors: | Hassan Malekinejad Soheyl Varasteh Fatemeh Rahmani Hadi Cheraghi Arash Alizadeh Mehdi Behfar |
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| Institution: | 1. Department of Pharmacology &2. Toxicology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran,;3. Division of Veterinary Pharmacy, Pharmacology and Toxicology, Faculty of Science, Utrecht University, Utrecht, The Netherlands,;4. Faculty of Science, Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands,;5. Department of Genetic, Faculty of Basic Sciences, Urmia University, Urmia, Iran,;6. Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran, and;7. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran |
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| Abstract: | This study was conducted to clarify the role of efflux transporter MRP2 in acetaminophen-induced hepatotoxicity in cats. Sixteen mixed bred male cats and four liver samples from mixed breed male dogs were used. The cats were assigned into four groups (n?=?4), received saline and 2, 10 and 50?mg/kg doses of acetaminophen orally for 14 days. Unlike the intact dogs, the MRP2 was not detectable in control cats. MRP2 at mRNA level was expressed in the liver of cats, which received the medium and high doses. Data suggest that the MRP2 expression may involve in the acetaminophen-induced hepatotoxicity in cats. |
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| Keywords: | Acetaminophen efflux transporter hepatotoxicity oxidative/nitrosative stress |
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