Impact of 13(S)-HPODE,a lipoxygenase product of linoleic acid,on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Impact of 13(S)-HPODE,a lipoxygenase product of linoleic acid,on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

Authors:	G. A. Cherednichenko A. A. Moibenko I. A. Butovich S. A. Ogii

Affiliation:	(1) Department of Experimental Cardiology, A. A. Bogomolets Institute of Physiology, Ukrainian Academy of Sciences, Kiev;(2) Laboratory of Chemical Enzymology, Institute of Bioorganic Chemistry and Petrochemistry, Ukrainian Academy of Sciences, Kiev

Abstract:	In thisin vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC₅₀=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca²⁺ transport and of membrane-bound enzymes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N^o 9, pp. 255–257, September, 1995 Presented by D. F. Chebotarev, Member of the Russian Academy of Medical Sciences

Keywords:	hydroperoxylinoleic acid sarcolemma Ca ²⁺ transport Na,K-ATPase
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