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| 口腔鳞癌中S100A4蛋白和E-cad的表达及意义 | |
| 引用本文： | 陈永锋,张令达,曹立宇.口腔鳞癌中S100A4蛋白和E-cad的表达及意义[J].临床与实验病理学杂志,2006,22(6):696-698. |
| 作者姓名： | 陈永锋 张令达 曹立宇 |
| 作者单位： | 1. 蚌埠医学院第一附属医院口腔科,蚌埠,233004 2. 安徽医科大学第一附属医院口腔颌面外科,合肥,230022 3. 安徽医科大学第一附属医院病理科,合肥,230022 |
| 摘 要： | 目的 探讨口腔鳞状细胞癌（oral squarnous cell carcinoma，OSCC）中S100A4蛋白和上皮钙粘蛋白（E—cadherin，E—cad）的表达及意义。方法 采用免疫组化SP法检测61例OSCC组织中S100A4、E—cad表达情况，分析二者的表达与临床病理特征之间的关系。结果 S100A4蛋白的表达与组织学分级无关（P〉0．05），与淋巴结转移呈正相关（P〈0．05）；E-cad的表达与组织学分级呈正相关（P〈0．05），与淋巴结转移呈负相关（P〈0．05）；S100A4蛋白和E—cad的表达呈负相关（P〈0．05）。结论 E-cad对OSCC的分化起重要作用；E-cad、S100A4蛋白和OSCC的侵袭和转移密切相关；S100A4蛋白和E-cad的表达与口腔鳞癌的进展密切相关，是判断口腔鳞癌生物学行为、预测转移趋势的有价值的指标。 |
| 关 键 词： | 口腔肿瘤 鳞状细胞癌 S100A4蛋白 上皮钙粘蛋白 免疫组织化学 |
| 文章编号： | 1001-7399(2006)06-0696-03 |
| 收稿时间： | 2006-03-15 |
| 修稿时间： | 2006-06-12 |
Expression of S100A4 and E-cad in oral squamous cell carcinoma and their significance |
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| CHEN Yong-feng,ZHANG Ling-da,CAO Li-yu.Expression of S100A4 and E-cad in oral squamous cell carcinoma and their significance[J].Chinese Journal of Clinical and Experimental Pathology,2006,22(6):696-698. | |
| Authors: | CHEN Yong-feng ZHANG Ling-da CAO Li-yu |
| Institution: | 1 Department of Stomatology , the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China ; 2 Department of Oral Dentofacial Surgery; 3 Department of Pathology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China |
| Abstract: | Purpose To discuss the expression of S100A4 and E-cad in oral squamous cell carcinoma (OSCC) and their significance.Methods Expression of S100A4 and E-cad was detected by using immunohistochemical SP method in oral squamous cell carcinoma.Correlation between the expression and clinicopathological features was analyzed.Results Expression of S100A4 had positive correlation with lymph node metastasis (P<0.05), and no correlation with histological grade(P>0.05). Expression of E-cad had positive correlation with histological grade and negative correlation with lymph node metastasis(P<0.05). Inverse relationship between S100A4 and E-cad expression was observed in oral squamous cell carcinoma(P<0.05).Conclusions E-cad plays an important role in differentiation of OSCC. E-cad and S100A4 is closely related to invasion and metastasis of OSCC. Expression of S100A4 and E-cadherin is significantly associated with tumor progression in oral squamous cell carcinoma,which are valuable markers in predicting biological behavior and trend of metastasis in OSCC. |
| Keywords: | mouth neoplasms squamous cell carcinoma S100A4 E-cadherin immunohistochemistry |
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