西酞普兰与氟西汀治疗首发老年抑郁症对照研究

目的探讨西酞普兰治疗首发老年抑郁症的疗效及安全性.方法将60例首发老年抑郁症患者随机分为研究组与对照组各30例,分别给予西酞普兰、氟西汀治疗,疗程均为6w.采用汉密顿抑郁量表、临床疗效总评量表及副反应量表评定临床疗效与不良反应.结果治疗第1、2w末研究组汉密顿抑郁量表评分较对照组下降明显（P＜0.05）,提示西酞普兰起效快于氟西汀.治疗6w末研究组有效率为93.3%,对照组为86.7%,两组疗效相当（χ^2=0.74,P＞0.05）.两组不良反应均较轻微（P＞0.05）.结论西酞普兰是一种安全有效的抗抑郁药,可作为治疗老年抑郁症的首选药物.

A control study of citalopram and fluoxetine in first-episode senile depression

Objective To explore the curative effects and safety of citalopram in first-episode senile depression. Methods Sixty first-episode senile depressive patients were randomly assigned into research (n=30, took citalopram) and control group (n=30, took fluoxetine) for 6 weeks. Clinical efficacy and side effects were assessed using the Hamilton Rating Scale (HAMD), the Clinical Global Impression Scale (CGI) and the Treatment Emergent Symptom Scale (TESS). Results At the ends of 1st and 2nd week treatment, score of the HAMD was significantly lower in the citalopram than in the fluoxetine group(P<0.05), which suggested citalopram took effects faster than fluoxetine did. At the end of 6th week, effective rates of citalopram and fluoxetine were respectively 93.3% and 86.7%, which showed no significant difference(P>0.05).Conclusion Citalopram is a safe and effective antidepressant and could be used as a first-line antidepressant in the treatment of senile depression.