卵泡晚期血清孕酮水平对体外受精、胚胎发育及妊娠结局的影响

目的:探讨控制性卵巢刺激中,卵泡晚期血清孕酮水平与体外受精、胚胎发育及妊娠结局的关系。方法:2008年1月～2009年4月在遵义医学院附属医院生殖中心接受体外受精助孕的不孕症患者88例,根据hCG注射日血清孕酮水平的不同分为两组,血清孕酮5.5nmol/L者67例(A组),血清孕酮≥5.5nmol/L者21例(B组),回顾性分析卵泡晚期血清孕酮水平对体外受精、胚胎发育及妊娠结局的影响。结果:A组的总受精率、正常受精率、早期卵裂率、优质胚胎率、胚胎种植率和临床妊娠率明显高于B组(P0.01)。结论:卵泡晚期血清孕酮水平升高对体外受精和胚胎发育具有负面影响,并导致胚胎种植率和临床妊娠率明显降低。

Impact of progesterone serum level during late follicular phase on in vitro fertilization,embryo development and pregnancy outcome

Objective:To evaluate the impact of progesterone (P) serum level during late follicular phase on in vitro fertilization,embryo development and pregnancy outcome.Methods:A total of 88 cases of IVF performed in our reproductive center from January 2008 to April 2009 were analyzed retrospectively in this study.Patients were divided into two groups according to progesterone serum level on the day of hCG administration,group A (P < 5.5 nmol/L,67 cases),group B (P≥5.5nmol/L,21 cases).Results:The total fertilization rate,normal fertilization rate,early cleavage rate,high quality embryo rate,implantation rate and clinical pregnancy rate in group A was much higher than that of group B (P < 0.01).Conclusion:Elevated progesterone serum level during late follicular phase adversely affects in vitro fertilization and embryo development,and results in a lower implantation rate and a lower clinical pregnancy rate.