| 长春地区1296例不育男性染色体分析 |
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| 引用本文： | 游红亮,张志红,王瑞雪,董媛,杜日成,刘睿智,张利群.长春地区1296例不育男性染色体分析[J].中国妇幼保健,2011,26(5):705-707. |
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| 作者姓名： | 游红亮 张志红 王瑞雪 董媛 杜日成 刘睿智 张利群 |
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| 作者单位： | 吉林大学第一医院生殖中心,吉林,长春,130021 |
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| 基金项目： | 吉林省科技发展规划项目 |
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| 摘 要： | 目的:研究染色体异常与男性不育之间的关系。方法:对在2007年3月~2010年3月期间,1 296例因不育前来吉林大学第一医院生殖中心进行遗传咨询的不育患者的外周血进行细胞培养(采用一生骏外周血淋巴细胞培养基),G显带核型分析。结果:1 296例患者中染色体核型异常120例,检出率为9.3%。其中性染色体异常98例,占咨询者的7.6%;常染色体异常22例,占咨询者的1.7%。120例染色体异常患者的核型分析结果显示,91例为47,XXY(其中3例为嵌合:2例核型为46,XY/47,XXY,1例核型为46,XX/47,XXY),所占的比例最多。结论:研究中不育男性的染色体异常比例与国内外报道相一致,且不育患者中染色体异常的比率高于正常人群。因此推荐不育男性进行常规的细胞遗传学检查,尤其是求助于卵胞浆内单精子注射技术(ICSI)等辅助生殖技术的患者。
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| 关 键 词： | 男性不育 染色体异常 核型分析 |
Chromosomal analysis on 1 296 infertile men in Changchun |
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| YOU Hong-Liang,ZHANG Zhi-Hong,WANG Rui-Xue et al.Reproductive Center,the First Affiliated Hospital of Jilin University,Changchun ,Jilin,China.Chromosomal analysis on 1 296 infertile men in Changchun[J].Maternal and Child Health Care of China,2011,26(5):705-707. |
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| Authors: | YOU Hong-Liang ZHANG Zhi-Hong WANG Rui-Xue Reproductive Center the First Affiliated Hospital of Jilin University Changchun Jilin China |
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| Institution: | YOU Hong-Liang,ZHANG Zhi-Hong,WANG Rui-Xue et al.Reproductive Center,the First Affiliated Hospital of Jilin University,Changchun 130021,Jilin,China |
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| Abstract: | Objective:To study the relationship between chromosomal abnormality and male infertility.Methods:The peripheral blood samples were extracted from 1 296 infertile men who searched for genetic counseling in the hospital from March 2007 to March 2010 for cell culture and G banding.Results:Among 1 296 cases,120 cases were found with abnormal chromosomal karyotype,the detection rate was 9.3%,including 98 cases with sex chromosome abnormality,accounting for 7.6% of all cases,22 cases with autosomal abnormality,ac... |
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| Keywords: | Male infertility Chromosome abnormality Karyotype analysis |
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