腰椎原发性前B淋巴母细胞性淋巴瘤1例报道并文献复习

目的:报道1例腰椎原发性前B淋巴母细胞性淋巴瘤并探讨其临床病理特点、诊断和鉴别诊断。方法:对1例腰椎原发性前B淋巴母细胞性淋巴瘤进行光镜、免疫组化检测和基因重排,并结合文献讨论。结果:镜下肿瘤细胞弥漫分布,细胞大小不一,胞质较丰富,核染色质呈粉尘状。免疫表型:肿瘤细胞CD99、LCA、CD20、CD79a弥漫阳性,CD3灶性阳性,VIM肿瘤细胞阴性,间质阳性,Ki-67增值指数为37%。结论:前B淋巴母细胞性淋巴瘤是一种罕见的高度恶性肿瘤,诊断和鉴别诊断主要依赖其病理形态学特点结合免疫表型。

Lumbar precursor B-Cell lymphoblastic lymphoma:a Case report and review of literature

Objective:To report a case of lumbar precursor B-cell lymphoblastic lymphoma and study its clinical and pathologic features,diagnosis and differential diagnosis.Methods:A case of lumbar precursor B-cell lymphoblastic lymphoma was studied by using light microscopy and immunohistochemical staining,gene rearrangement,with review of literature.Results:The tumor cells with abundant cytoplasm and dust-like chromatin were distributed asystematically and unevenly.Immunophenotype staining showed that the tumor cells were asystematically positive for CD99,LCA,CD20,CD79a and focally positive for CD3.While Vimentin was negative in tumor cells,positive in stroma.Conclusion:Precursor B-cell lymphoblastic lymphoma is a rare malignant tumor.The diagnosis and differential diagnosis are based on pathological morphology and immunophenotype examination.