| 乳腺浸润性导管癌中促性腺激素释放激素受体的表达及意义 |
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| 引用本文： | 祝明洁,许恪淳,虞文伟,姚俊宇,姚晓虹. 乳腺浸润性导管癌中促性腺激素释放激素受体的表达及意义[J]. 临床与实验病理学杂志, 2009, 25(1) |
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| 作者姓名： | 祝明洁 许恪淳 虞文伟 姚俊宇 姚晓虹 |
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| 作者单位： | 上海交通大学医学院新华医院病理科,200092;上海交通大学医学院新华医院病理科,200092;上海交通大学医学院新华医院病理科,200092;上海交通大学医学院新华医院病理科,200092;上海交通大学医学院新华医院病理科,200092 |
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| 摘 要： | 目的 探讨促性腺激素释放激素受体(gonadotropin-releasing hormone,GnRHR)在乳腺浸润性导管癌中的表达及意义.方法 采用免疫组化方法 检测50例乳腺浸润性导管癌及18例正常乳腺组织中的GnRHR.结果 乳腺浸润性导管癌中GnRHR的阳性表达为68%(34/50).其中乳腺癌 G1组的阳性表达(92.3%,12/13)与G3组的阳性表达(46.2%,6/13)之间的差异有统计学意义(P<0.05).乳腺癌G3组的阳性表达和正常乳腺组织的阳性表达(94.4%,17/18)之间的差异有统计学意义(P<0.01).结论 大多数正常乳腺组织的GnRHR虽有表达,但呈弱阳性表达,而多数浸润性导管癌GnRHR则呈强阳性表达,提示乳腺组织的分化程度影响肿瘤组织内GnRHR的表达.
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| 关 键 词： | 乳腺浸润性导管癌 促性腺激素释放激素受体 免疫组织化学 |
Expression and significance of GnRHR in breast invasive duct carcinoma |
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| ZHU Ming-jie,XU Ke-chun,YU Wen-wei,YAO Jun-yu,YAO Xiao-hong. Expression and significance of GnRHR in breast invasive duct carcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2009, 25(1) |
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| Authors: | ZHU Ming-jie XU Ke-chun YU Wen-wei YAO Jun-yu YAO Xiao-hong |
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| Affiliation: | Department of Pathology;Xinhua Hospital;Shanghai Jiaotong University;Shanghai 200092;China |
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| Abstract: | Purpose To investigate the expression and significance of GnRHR in breast carcinoma.Methods Immunohistochemical method was used to detect GnRHR expression in 50 cases of breast invasive duct carcinoma and 18 cases of normal breast tissue.Results The positive rate of GnRHR expression was 68% in breast invasive duct carcinoma.The positive rates of GnRHR in G1 group and G3 group were 92.3% and 46.2%,respectively,and there was significant difference between them(P<0.05).There was also significant difference bet... |
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| Keywords: | breast invasive duct carcinoma GnRHR immunohistochemistry |
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