103例乳腺癌组织学与雌激素受体的研究

应用生物素抗生物素过氧化酶法对103例乳腺癌石蜡切片进行雌激素受体检测,结果发现雌激素受体阳性率在导管内癌中较高,占71%,而在浸润性导管癌、髓样癌中较低,分别占57%、29%。分析了雌激素受体和组织类型关系,探讨了它和组织分级及核分级之间的联系。雌激素受体阳性率随组织分级升高而降低,随核的分级升高而增加。说明乳腺癌组织分化好,雌激素受体表达倾向阳性,而分化低的肿瘤,雌激素受体表达倾向阴性。雌激素受体阳性患者比阴性患者复发率低,存活时间长,预后好,其检测有助于判断患者预后,安排合理的治疗方案,提高治愈率。

Studies on the Histology & Estrogen Receptor in 103 Breast Cancer

In an attempt to investigate relationship between ER and thebiologic behavior of breast cancer,103 cases of breast carcinomaswere reviewed On parafin-embeded tissue blocks with avidin-biotincomplex method for estrogen receptor.A positive correlation was confirmed between ER content andhistologic type or degree of histologic differentiation.There were more positive cases in the well differentiated tumorswere the poor differentiated ones.In addition,patients with ER-positive tumors have a lower re-currence rate and better survival than patients with ER-negativetumors.The paper suggests that ABC method to detect ER is simple,sen-sitive and of practical value & may preserv morphologic details totrace ER under microscope.