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Sjogren's syndrome and the sicca syndrome: The role of prostaglandin El deficiency. Treatment with essential fatty acids and vitamin C
Authors:D.F. Horrobin  A. Campbell
Affiliation:1. PO Box 10, Nuns'' Island, Montreal H3E 1J8, Canada;2. Hairmyres Hospital, East Kilbride, Glasgow, Scotland.
Abstract:
Lack of adequate synthesis of prostaglandin (PG) El may be the key factor in Sjogren's syndrome. PGEl is important for lacrimal and salivary gland secretion and for T lymphocyte function: a deficiency could therefore account for the main features of Sjogren's syndrome and the sicca syndrome. PGEl could also account for many of the other features often associated with these syndromes. These include the Raynaud's phenomenon, the abnormalities of renal function and the precipitation of the syndrome by vitamin C deficiency. Vitamin C is important in PGEl biosynthesis. PGEl treatment has been shown to correct the immunological abnormalities in the NZBW mouse, the animal model ·of Sjogren's syndrome. An attempt to treat humans with Sjogren's syndrome by raising endogenous PGEl production by administration of essential fatty acid PGEl precursors, of pyridoxine and of vitamin C was successful in raising the rates of tear and saliva production.
Keywords:
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