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Sister chromatid exchanges in patients with retinoblastoma |
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| Authors: | Hera Der-Sarkissian Catherine Bonaïti-Pellié Marie-Louise Briard-Guillemot Jean-Michel Zucker |
| Affiliation: | 1. Groupe de Recherches de Gńétique Epidémiologique, INSERM, Château de Longchamp, Paris, France;2. Unité de Recherches de Génétique Médicale, INSERM, Hôpital des Enfants-Malades, Paris, France;3. Service de pédiatrie oncolgique, Institute of Curie, Paris, France |
| Abstract: | Spontaneous and mitomycin C(MMC)-induced sisyer chromatid exchanges were studied in 11 patients with retinoblastoma and 7 normal controls. Spontaneous rates were similar in patients and in controls. The MMC-induced rate was found to be significantly higher in bilaterally affected patients than in controls. It is suggested that this increase may be due to a DNA repair deficiency. However, it is not possible to clarify wether this abnormality is associated with the retinoblastoma gene or with another factor acting on the degree of expressivity of the disease in gene carriers. |
| Keywords: | Address request for reprints to Dr. C. Bonaïti-Pellié Groupe de Recherches de Génétique Epidémioloque U. 155 INSERM Château de Longchamp Bois de Boulogne 75016 Paris. |
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