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不同年龄大鼠耳蜗核细胞的定量观察
引用本文:方耀云 杨旭春. 不同年龄大鼠耳蜗核细胞的定量观察[J]. 临床耳鼻咽喉头颈外科杂志, 1997, 11(3): 99-102
作者姓名:方耀云 杨旭春
作者单位:[1]北京解放军耳鼻咽喉科研究所 [2]广州海军421医院
摘    要:分别对幼年,成年及老年大鼠耳蜗核的体积,神经元的核仁体积和耳蜗核神经元的数量进行检测。结果示:老年大鼠耳蜗核体积与成年组相关无显著性意义;神经地核仁体积,老年组较其它两组有极显著性缩小;老年组球形细胞和多极细胞无明显减少;梭形细胞与其它两组相差无显著意义,而胶质细胞极明显增多,平均增多48.5%。表明老年性聋的病理变化不仅发生在耳蜗,而且发生在蜗神经核。

关 键 词:大鼠 耳蜗神经核 定量 神经元 老年性耳聋

A quantitative study on the cells of cochlear nucleus in rats at different ages
Fang Yaoyun,Yang Xuchun,Jiang Sichang et al. A quantitative study on the cells of cochlear nucleus in rats at different ages[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 1997, 11(3): 99-102
Authors:Fang Yaoyun  Yang Xuchun  Jiang Sichang et al
Abstract:The volume of cochlear nucleus and nucleolus,neural populations were determined in rats of three groups aged(1, 2-3, 22-28 months). The study data indicated that there is no dif ference between the volume of cochlear nucleus in the aged and adult animals (P>0.05). Com pared with the other two groups, the aged animals show a reduction of volume of necleolus of cochlear nucleus neurons (P<0.01), a loss of neurons (spherical cell and multipolar cell) (P< 0. 01). On the other hand, it shows an increase in number for the glial cells in the aged animals (48. 48%, P<0. 01). Quantitative results of the cell of cochlear nucleus were analysed. We sug gest that central changes also play an important role in presbycusis.
Keywords:Rat Cochlear nucleus Quantitative study Neuron Presbycusis
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