子宫内膜息肉中雌激素受体和孕激素受体的表达特点及意义

目的通过探讨雌、孕激素在子宫内膜息肉(EP)发生发展中的作用机制,试图为子宫内膜息肉的治疗方法提供理论依据。方法前瞻性研究EP患者56例,全部患者均接受宫腔镜下子宫内膜息肉切除术(TCRP),切除息肉及周围内膜组织。运用免疫组化方法测定EP组织和周围内膜组织中雌激素受体(ER)、孕激素受体(PR)的表达水平。同时所有病例均采用酶联免疫测定法测定血清6项性激素。结果ER在息肉组及内膜组中腺体及间质上的表达均无差异。PR在息肉组中腺体及间质上的表达均低于内膜组,差异有统计学意义(P<0.05)。EP患者的血清6项性激素检测结果均属正常水平。结论EP的发生发展可能与局部子宫内膜对周期性变化的雌、孕激素不敏感有关。PR在子宫内膜息肉组中的异常表达与EP的形成可能有关。

The Expression and Significance of Estrogen Receptor, Progesterone Receptor in the Mechanism of Pathogenesis of Endometrial Polyps

Objective To investigate the causes and possible mechanism and pathogenesis of endometrial polyps(EP) by evaluating the expression of estrogen receptor(ER),progesterone receptor(PR) so as to try to find the theoretical basis for the treatment and prevention of EP.Methods Prospective study was performed 56 patients,who had transcervical resection of polyps(TCRP) were enrolled.EP and pieces of endometrium had been removed in all operations.Routine pathological diagnosis to all specimens and immunohistochemical staining studies for ER,PR expression in EP and endometrium were made.Serum sex hormones were measured for all patients.Serum sex hormone in 56 patients were all in normal level.Results Expression of ER in gland and stroma of the two groups showed no significant difference(P>0.05).Expression of PR in gland and stroma were significantly decreased in EP group(P<0.05).Conclusion The main mechanisms of EP may be local endometrium wasn't sensitive to the periodic changes of steroid.Abnormal expressions of PR in EP were probably associated with EP formation.