氨基磺酸催化绿色合成3，4-二氢嘧啶-2-酮

目的使用氨基磺酸（H2NSO3H,SA）为催化剂，在水相中绿色合成一系列新的Biginelli反应产物——3，4-二氢嘧啶-2-酮类化合物。方法以醛、酮酯和尿素为原料，SA为催化剂，微波辐射，水相中合成目标化合物。结果反应8～17min完成，产率81％-92％，所有产物均通过熔点、红外光谱和氢核磁共振谱等表征检测确认结构。结论提供了一种氨基磺酸催化，水相中清洁合成二氢嘧啶酮的方法。催化剂使用方便、经济，环境友好。

Green synthesis of 3, 4-dihydropyrimidin-2-ones catalyzed by sulfamic acid

： Objective To develop a method of green synthesis of the title compounds, 3, 4 - dihydripyrimidin - 2 -ones in aqueous media using sulfamic acid （H2NSO3 H, SA） as catalyst for the Biginelli reaction. Methods The target compounds were synthesized via one - pot three components reactions by the mixture of aldehyde, keto esters and urea in water and under microwave irradiation in the presence of a catalytic amount of H2 NSO3 H. Results The reactions were completed in 8 - 17 rain with yields of 81% - 92%. The structures of the products were determined by M. P. , IR and 1H NMR spectra. Conclusion The use of SA as a catalyst for the green synthesis of 3, 4 - dihydropyrimidin - 2 - ones makes the process convenient, economical and environmentally friendly.