糖平煎对2型糖尿病大鼠血清游离脂肪酸、瘦素、白介素-6和肿瘤坏死因子-α的影响

目的:观察糖平煎对2型糖尿病(T2DM)大鼠血清游离脂肪酸(FFA)、瘦素(Leptin)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法:采取高热量饲料喂养结合小剂量链脲佐菌素(STZ)腹腔注射的方法复制T2DM大鼠模型,随机分为对照组、模型组及糖平煎大(HTPJ组)、小剂量组(LTPJ组),连续治疗4周。观察大鼠血清FFA、Leptin、IL-6和TNF-α水平的变化。结果:糖平煎能明显降低血清FFA、Leptin、IL-6、TNF-α,与模型组比较有显著性差异(P0.05,P0.01)。结论:糖平煎可以改善T2DM大鼠脂毒性,降低血清炎症因子(Leptin,IL-6,TNF-α)的水平,这可能是其影响机体脂代谢过程,改善胰岛素抵抗(IR)的机制之一。

Effects of Tangpingjian on serum free fatty acid,leptin,interleukin-6 and tumor necrosis factor-alpha in rats with type 2 diabetes mellitus

Objective: Observing the effects of Tangpingjian(TPJ) on serum free fatty acid(FFA),leptin,interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α) in rats with type 2 diabetes mellitus(T2DM).Methods: Reconstructing the T2DM rat model by adopting the method of feeding them with high calorie forage combined with low-dose streptozotocin(STZ) intraperitoneal injection.The rats were divided into four groups: normal control group,model control group,high-dose TPJ group and low-dose TPJ group.Then they were given successive treating with TPJ for 4 weeks,and the serum FFA,leptin,IL-6 and TNF-α of rats were measured.Results: TPJ could decrease serum FFA,leptin,IL-6 and TNF-α remarkably in experimental rats,and it had significant differences compared with model group(P<0.01,P<0.05).Conclusion: TPJ can decrease lipid toxicity in the rats and reduce the level of serum inflammation factors(Leptin,TNF-a,IL-6),which might be one of its mechanisms that it has effects on the process of body fat metabolism and improvement of insulin resistance(IR).