不同剂量雷公藤多甙治疗难治性肾病综合征疗效分析

目的探讨不同剂量的雷公藤多甙对难治性肾病综合征的疗效差异。方法回顾性分析78例经标准激素治疗无效的肾病综合征患者的基线Ser、24 h尿蛋白和按不同剂量加用雷公藤多甙治疗后的疗效。人为地分为常规剂量组(雷公藤多甙20 mg,每日3次)和高剂量组(雷公藤多甙30 mg,每日3次)并对两组的疗效进行比较。结果共有78例患者入组。高剂量组完全缓解15例(44.12%),部分缓解14例(41.17%),无效5例(14.71%),有效率为85.3%。常规剂量组完全缓解9例(26.47%),部分缓解12例(35.29%),无效13例(38.24%),有效率为61.76%。(85.3%vs 61.76%,χ2=4.83,P0.05)。两组间的不良反应差异无统计学意义。结论适当增加雷公藤多甙的剂量可以明显地提高难治性肾病综合征患者治疗的有效率,且不良反应无明显增加。值得临床进一步研究。

Efficacy analysis of different doses of Tripterygiumglycosides in refractory nephrotic syndrome

Objective To investigate the efficacy differences of different doses of Tripterygiumglycosides in refractory nephrotic syndrome.Methods Clinical data of 78 nephrotic syndrome patients’ baseline Ser,24 h urine protein and the curative effect after the treatment according to different doses of Tripterygiumglycosides were analyzed retrospectively.The standard steroid therapy for these patients was ineffective.These patients were artificially divided into conventional dose group(Tripterygiumglycosides,20mg,three times a day) and high dose group(Tripterygiumglycosides,30mg,three times a day) and the efficacy of the two groups was compared.Results There were 78 patients.In the high dose group,15 patients(44.12%) were with complete remission,14 patients(44.17%) were with partial remission,and 5 patients(14.71%) were without remission.The efficiency rate was 85.30%.In the conventional dose group,9 patients(26.47%) were with complete remission,12 patients(35.29%) were with partial remission,and 13 patients were without remission.The efficiency rate was 61.76 %.(85.30% vs 61.76%,χ2 =4.83,P<0.05).Difference in adverse reactions was not significant between the two groups.Conclusion Proper increase of Tripterygiumglycosides can obviously improve the efficacy of the treatment for nephrotic syndrome patients and the adverse reactions are not increased obviously.It is worthy for further clinical study.