葡萄膜与结膜色素性肿瘤核仁组成区银染定量研究

目的：评价银染核仁组成区(AgNORs)和计算机图像分析技术在结膜与葡萄膜色素性肿瘤良恶性鉴别诊断或冒后评估上的价值．方法：应用AgNORs和计算机图像分析技术对44例葡萄膜恶性黑色素瘤、10例结膜色素痣及10例结膜恶性黑色索瘤进行检测。结果：结膜恶性黑色素瘤较色素痣AeNORs面积显著增加(P<0.05)；葡萄膜恶性黑色索瘤AgNORs面积则按梭形细胞型、混合细胞型及上皮样细胞型顺序增加(P<0.05).结论：AeNORs技术可能有助于结膜黑色素瘤良恶性的鉴别诊断，井可作为葡萄膜恶性黑色索瘤预后评价的参数之一。（中华眼底病杂志，1995，11：181-184）

QUANTITATIVE STUDY OF SILVER-STAINED NUCLEOLAR ORGANIZER REGIONS IN UVEAL AND CONJUNCTIVAL PIGMENTAL TUMORS

PURPOSE:To evaluate the value of the silver-stained nucleolar organizer regions(AgNORs)and computer-assisted image analysis techniques in an attempt to distinguish between bening and malignant or to estimatc prognosis of conjunctival and uveal pigmental tumors. AETH-ODS:The AgNORs and computer-assisted image analysis techniques were performedto detect 44 cases of uveal malignant melanoma, 10 cases conjunctival nevi and 10 cases of conjunctival malig-nant melanomal RESULTS:The AgNORs areas in cnjunctival malignant melanomas were much higher than those in conjunctival nevi(P<0.05);the AgNORs ares in uveal malignant melanomas increased gradually in order of spindle-cell type,mixed-cell type and epithelial-cell type(P<0.05).CONCLUSION:The AgNORs technique may be helpful in discriminating benign from malignant conjunctival melanomas and in predicting prognosis for uveal malignant melanomas.