| 微透析技术对芎冰微乳在清醒大鼠脑局部的药动学研究 |
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| 引用本文： | 王利胜,赖宝林,夏祖猛,张升,吴阳,程龙,田瑶.微透析技术对芎冰微乳在清醒大鼠脑局部的药动学研究[J].中药新药与临床药理,2011,22(3). |
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| 作者姓名： | 王利胜 赖宝林 夏祖猛 张升 吴阳 程龙 田瑶 |
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| 作者单位： | 广州中医药大学中药学院,广州,510006 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的 评价芎冰微乳灌胃、静脉注射和鼻腔给药三种不同给药途径川芎嗪(TMP)在脑部的药动学特性.方法 采用脑微透析取样技术,以清醒大鼠为实验模型,连续收集三种给药途径大鼠脑纹状体透析液,HPLC法测定TMP浓度,经回收率校正后,用DAS2.1药动学软件计算主要药动学参数.结果 灌胃、静注和鼻腔给药TMP在脑内药动学过程均符合一室模型,MRT0-∞分别为73.7,38.8,70.6 min;Tmax分别为15,5,15 min;Cmax分别为249.2,2579.3,1175.1μg·L-1,AUC0-∞分别为19806.9,106410.7,62973.3 μg·min·L-1,TMP在脑组织中的局部生物利用度显示,鼻腔给药为59.2%,灌胃给药为18.6%.结论 芎冰微乳灌胃给药生物利用度较低;静脉注射TMP入脑迅速,生物利用度最高,但代谢迅速,作用时间短;鼻腔给药生物利用度较高,且脑内作用时间较长,具有一定的研究价值.
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| 关 键 词： | 芎冰微乳 川芎嗪 给药途径 微透析 药动学 |
Studies on Brain Pharmacokinetics of Xiongbing Microemulsion by Microdialysis Technique in Awake and Freely-moving Rats |
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| WANG Lisheng,LAI Baolin,XIA Zumeng,ZHANG Sheng,WU Yang,CHENG Long,TIAN Yao.Studies on Brain Pharmacokinetics of Xiongbing Microemulsion by Microdialysis Technique in Awake and Freely-moving Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(3). |
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| Authors: | WANG Lisheng LAI Baolin XIA Zumeng ZHANG Sheng WU Yang CHENG Long TIAN Yao |
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| Institution: | WANG Lisheng,LAI Baolin,XIA Zumeng,ZHANG Sheng,WU Yang,CHENG Long,TIAN Yao(School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To investigate the brain pharmacokinetics of tetramethylpyrazine(TMP) in Xiongbing Microemulsion after intragastric(i.g.),intravenous(i.v.) and intranasal(i.n.) administration.Methods Striatum dialysate samples were continuously collected by brain microdialysis technique in awake and freely-moving rats after the three routs of administration.The concentration of TMP in dialysate samples were measured by HPLC.The pharmacokinetic parameters were calculated by pharmacokinetic software DAS2.1.Results ... |
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| Keywords: | Xiongbing Microemulsion Ligustrazine Methods of administration Microdialysis technique Pharmacokinetics |
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