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| 类风湿性关节炎患者外周血TH1/TH2细胞的研究 | |
| 引用本文： | 毛立群,冯玲,闫燕华.类风湿性关节炎患者外周血TH1/TH2细胞的研究[J].免疫学杂志,2002,18(Z1):30-31. |
| 作者姓名： | 毛立群 冯玲 闫燕华 |
| 作者单位： | 1. 武警医学院免疫学教研室,天津,300162 2. 天津医科大学总医院内科,天津,300070 3. 天津医科大学免疫学教研室,天津,300070 |
| 摘 要： | 目的探讨CD4+TH1/TH2细胞在类风湿性关节炎(RA)发生发展过程中的作用.方法采用酶联免疫斑点法(ELISPOT)对15例RA患者和30例健康人外周血中T淋巴细胞亚群及CD4+TH1/TH2功能亚型进行检测.结果RA患者外周血中TH1细胞的百分率较正常对照组升高(P＜0.05).结论 TH1细胞介导的细胞免疫可能与RA的发生发展有关. |
| 关 键 词： | 类风湿性关节炎 TH1细胞 TH2细胞 |
| 文章编号： | 1000-8861(2002)03(S)-0030-03 |
| 修稿时间： | 2001年10月15 |
Type 1 and type 2 T helper cells in peripheral blood of patients with rheumatoid arthritis |
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| MAO Li qun,FENG Ling,YAN Yan hua.Type 1 and type 2 T helper cells in peripheral blood of patients with rheumatoid arthritis[J].Immunological Journal,2002,18(Z1):30-31. | |
| Authors: | MAO Li qun FENG Ling YAN Yan hua |
| Abstract: | Objective To investigate the action of type 1 and type 2 CD4 + T helper cells in the pathogenesis of rheumatoid arthritis. Methods T lymphocyte subsets and CD4 +T helper functional subsets (including T H1 and T H2 cells) in peripheral blood from 15 cases of patients with rheumatoid arthritis(RA) and 30 cases of healthy people were detected by enzyme linked immunospot assay(ELISPOT). Results Compared with those of normal control, the percentages of T H1 cells among patients with RA were increased( P <0.05). Conclusion The occurrence of RA might be associated with increased cellular immune function mediated by T H1 cells. |
| Keywords: | rheumatoid arthritis type 1 T helper cells type 2 helper cells |
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