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Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users
Authors:Morice Yoann  Cantaloube Jean-François  Beaucourt Stéphanie  Barbotte Laetitia  De Gendt Sija  Goncales Fernando Lopes  Butterworth Lesley  Cooksley Graham  Gish Robert G  Beaugrand Michel  Fay Fabian  Fay Oscar  Gonzalez Jorge E  Martins Regina Maria Bringel  Dhumeaux Daniel  Vanderborght Bart  Stuyver Lieven  Sablon Erwin  de Lamballerie Xavier  Pawlotsky Jean-Michel
Affiliation:Department of Virology & INSERM U635, French National Reference Center for Viral Hepatitis B, C and delta, H?pital Henri Mondor, Université Paris 12, Créteil, France.
Abstract:
Hepatitis C virus subtype 3a (HCV-3a) originates from Asia and has spread widely among injecting drug users as well as other patient groups in industrialized countries. HCV subtype 3a infection remains highly prevalent and frequently transmitted in the population of intravenous drug users. The objective of this study was to understand better the mechanisms of the worldwide HCV-3a epidemics in drug users. Ninety-three sera from HCV-3a-infected IDUs from France, the United States, Brazil, Argentina, and Australia were studied. Phylogenetic analyses of the non-structural 5B region showed no specific clustering according to the continent of the patient's origin. Non-exclusive clusters of viral sequences from South America, Australia, and California were observed, but topologies were not supported by strong bootstrap values. The results suggest that HCV-3a has been transmitted from a common origin through a unique worldwide epidemic that rapidly spread among drug users. Regional transmission occurred in the recent past, leading to an embryonic genetic diversification of HCV-3a among local injecting drug user population.
Keywords:hepatitis C virus  subtype 3a  molecular epidemiology
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