穿心莲抗血小板聚集功能的研究

通过对体外纽61例和体内组8例的实验观察,我们发现穿心莲提取物对ADP 诱导的血小板聚集反应有显著的抑制作用(P<0.001)。在体外,这种作用的程度稍强于川芎嗪、潘生丁注射液。穿心莲还可增强纤溶系统活力。

Study on Antiplatelet Aggregation Effect of Andregraphis paniculata

This article deals with the antiplatelet aggregation effect of Audregraphis paniculata(AP),61 blood samples and 8 volunteers were investigated to observe the effect of AP on piatelet function in vitro and in vivo respectively.The results showed that the crude extract of AP could inhibit significantly one-phase and two-phase platelet aggregation induced by ADP(P<0.001,0.01).The potency of AP crude extract seemed to be somewhat stronger than Ligustrazine and Persantin injection in vitro,but the difference was not statistically significant(P>0.05).A dose-effect relation- ship of AP was demonstrated also(r=0.93). The rapid effect of this drug on platelet aggregation in vivo suggested that AP could be absorbed quickly,but the effect lasted for only a short time.12 hours after with-drawing of AP,the 1 minute and 5 minutes aggregation rates increased by 18.67%,36.63% respectively,as compared with the lowest aggregation rate after administration.The activating effect of AP on fibrinolysis was also detected by shortened euglobulinlysis time(211.50 vs 182.50 min in vitro,219.38 vs 149.38 min in vivo, P<0.001).In addition,the influence of AP upon coagulation and thrombelastogram was determined. This study suggested that AP in a promising antithrombogenic agent.This drug might be beneficial in preventing and treating arterial thrombotic diseases.