| 两种预防新生儿眼炎药物的体外抗菌活性比较 |
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| 引用本文： | 林彩,罗东,钟履华.两种预防新生儿眼炎药物的体外抗菌活性比较[J].中国药学杂志,1999,0(2):111-112. |
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| 作者姓名： | 林彩 罗东 钟履华 |
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| 作者单位： | 重庆400038第三军医大学西南医院药剂科 |
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| 摘 要： | 目的:测定并比较2种用于预防新生儿眼炎的药物的体外抗菌活性。方法:采用肉汤二倍稀释法测定最低抑菌浓度和最低杀菌浓度。结果:硝酸银滴眼液对新生儿眼炎常见致病菌金葡菌、肺炎球菌与淋球菌的MIC50为<4～8μg·ml-1,MBC90为8～32μg·ml-1;聚维酮碘滴眼液对受试菌的MIC50为64～256μg·ml-1,MBC90为512μg·ml-1。结论:硝酸银滴眼液和聚维酮碘滴眼液对新生儿眼炎常见致病菌都具抑菌和杀菌作用,但硝酸银作用更强。
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| 关 键 词： | 新生儿眼炎 抗菌活性 聚维酮碘 |
| 收稿时间： | 1997-11-03; |
The comparision of in vitro antibacterial activities of two drugs for ophthalmia neonatorum prophylaxis |
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| Lin Cai,Luo Dong,Zhong Lühua.The comparision of in vitro antibacterial activities of two drugs for ophthalmia neonatorum prophylaxis[J].Chinese Pharmaceutical Journal,1999,0(2):111-112. |
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| Authors: | Lin Cai Luo Dong Zhong Lühua |
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| Institution: | (Lin C),Luo Dong(Luo D),Zhong Luhua(Zhong LH |
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| Abstract: | OBJECTIVE:To eualuate in vitro antibacterial activities of silver nitrate and povidone-iodine for preventing ophthalmia neonatorum. METHODS:Minimal inhibitory concentration(MIC) and mininmal bactericidal concentration (MBC) were deter-mined by double broth dilution method. RESULTS:For Stapanrens Streppnenmonia and N gonorhveae,the MIC50 of silver nitrate were＜4～8μg.ml－1 and its MIC90 were 8～32μg.ml－1.The MIC50 of povidone-iodine were64～256μg.ml－1 and its MBC90were 512 μg.ml-1. CONCLUSION: Silver nitrate and povidone-iodine exhibited activities against common pathogens of ophthalmia neonatorum isolates.Silver nitrate was more active than povidone-iodine. |
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| Keywords: | ophthalmia neonatorum in vitro antibacterial activity povidone iodine silver nitrate |
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