无症状高尿酸血症与男性血清睾酮及血脂水平相关性分析

目的：探讨无症状高尿酸血症与男性血清睾酮（T）及血脂水平的相关性。方法收集2012年10月-2014年6月来广西医科大学第四附属医院（以下简称“我院”）进行健康体检的男性无症状高尿酸血症患者43例为研究组，选取同期来我院进行健康体检的尿酸正常的男性健康人员43名为对照组。检测两组患者尿酸（UA）、性激素及血脂水平并探讨UA与血清T、血脂水平的相关性。结果研究组血脂异常发生率（74.42%）与对照组（39.53%）比较明显较高，两组差异有统计学意义（χ2=10.67，P〈0.05）。性激素水平及血脂水平：研究组T水平与对照组比较明显降低，两组差异有统计学意义（t=4.728，P〈0.05）；研究组总胆固醇（TC）、三酰甘油（TG）水平与对照组比较明显升高，两组差异有统计学意义（t=5.627、3.185，P〈0.05）。相关性分析：研究组UA与T呈显著负相关（r=-0.498，P〈0.05），与TC、TG、低密度脂蛋白胆固醇（LDL-C）呈显著正相关（r=0.628、0.539、0.687，P〈0.05）。结论无症状高尿酸血症与男性血清T及血脂水平密切相关，存在低T水平及血脂紊乱，应提高UA检测的重视程度。无症状高尿酸血症患者还应重视T水平的检测。

Analysis of the correlation between the asymptomatic hyperuricemia and levels of male serum testosterone and serum lipid

Objective To investigate the correlation between the asymptomatic hyperuricemia and levels of male serum testosterone （T） and serum lipid. Methods 43 male patients of asymptomatic hyperuricemia with healthy examination from October 2012 to June 2014 in the Fourth Affiliated Hospital of Guangxi Medical University （“our hospital” for short） were collected as the study group, 43 healthy male people with normal uric acid level in healthy examination during the same period in our hospital were collected as the control group. The uric acid （UA）, sex hormones and serum lipid indexes of the two groups were detected, and the correlation between the UA level and serum T level or serum lipid level were explored. Results The incidence of dyslipidemia in the study group （74.42%） was significantly higher than 39.53%in the control group, there was significant difference between the two groups （χ2=10.67, P〈0.05）. Sex hor-mone levels and serum lipid levels： the level of T in the study group was significantly lower than that in the control group, there was significant difference （t=4.728, P〈 0.05）, the level of total cholesterol （TC） and triglycerides （TG） in the study group were significantly higher than those in the control group, there were significant differences （t=5.627, 3.185, P〈 0.05）. Correlation analysis： the level of UA in the study group was significantly negatively correlated with the level of T （r=-0.498, P〈0.05）, the level of UA and TC, TG, LDL-C in the study group showed significant positive correlation （r=0.628, 0.539, 0.687, P〈0.05）. Conclusion Asymptomatic hyperuricemia is closely associated with the levels of serum T and serum lipid, and has the presence of low T level and dyslipidemia, so the detection of UA level should be attached great importance, and asymptomatic hyperuricemia patients should also pay attention to the detection of T level.