高龄老年人脑梗死与颈动脉粥样硬化斑块及血浆纤维蛋白原水平的关系

目的探讨高龄老年人脑梗死与颈动脉粥样硬化斑块及血浆纤维蛋白原水平的关系。方法对64例高龄老年脑梗死患者和40例对照组患者进行颈动脉彩色多普勒超声检查,同时检测两组的血浆纤维蛋白原含量。结果脑梗死组中56例检出粥样硬化斑块(87.5%),显著高于对照组斑块检出率15.0%(6/40)(P<0.01),其中脑梗死组中软斑块检出率也显著高于对照组(P<0.01),脑梗死组的血浆纤维蛋白原水平也明显高于对照组(P<0.05)。结论颈动脉粥样硬化斑块与高龄老年人脑梗死的发生明显相关。血浆纤维蛋白原在颈动脉粥样硬化斑块的形成发展中可能起着重要作用。

Relationships between cerebral infarction and carotid artery atheroclerosis plaques and plasma fibrinogen level in aging patients

Objective To explore the relationships between cerebral infarction and carotid artery atherosclerosis plaque and plasma fibrinogen level in aged patients.Methods 64 aged patients with cerebral infarction and 40 control people without cerebral infarction were examined with Color Doppler Ultrasound in the carotid artery,meanwhile their plasma fibrinogen contents were detected.Results The carotid artery atherosclerosis plaques were found in 56 of 64 cerebral infarction patients（87.5%）,and only in 6 of 40 control people（15.0%）.The probability of carotid artery atherosclerosis plaque in the cerebral infarction group was signifancantly higher than that in the control group（P〈0.001）.Compared with the control group,the soft carotid artery atheroclerosis plaque was much more fonud in the cerebral infarction group（P〈0.01）,and the plasma fibrinogen level was also higher in the cerebral infarction group than that in control group（P〈0.05）.Conclusions Cerebral infarction is highly related to carotid artery atherosclerosis plaque,plasma fibrinogen may play an important role in the formation and development of carotid artery atherosclerosis plaque.