老年人2型糖尿病患者血糖波动与心脏功能的关系

目的探讨老年人2型糖尿病患者血糖波动状态对心功能的影响。方法选取88例老年人2型糖尿病患者,采用动态血糖监测系统(CGMS)进行72 h连续血糖监测,并按照血糖波动系数(BGFC)分为C组(BGFC≤1.5)、SD1组(1.5

The association between glucose fluctuation and cardiac function in the aged patients with type 2 diabetes mellitus

Objective To explore the relationship between glucose fluctuation and cardiac function in patients with type 2 diabetes mellitus.Methods 88 elderly diabetes mellitus patients,who were measured by continuous glucose monitoring system（CGMS）for 3 days,were divided into C group（BGFC≤1.5）,SD1 group（1.5BGFC3.0）and SD2 group（BGFC≥3.0）by blood glucose wavy coefficient（BGFC）in different levels.Echocardiography was performed in all of these patients to measure the cardiac structure and function.The investigations for the association between BGFC and cardiac function parameters were carried out.Results（1）There were significant differences in the mean level of 24hours blood glucose,the percentage of high glycemic time,the mean level of glucose fluctuation and the mean level of postprandial glucose fluctuation among these three groups（P〈0.01）.BGFC was significantly positively correlated with all the four parameters of CGMS above（P〈0.01）.（2）There were significant differences in LAD,LVDEd,LVDEs,IVS,LVPW and LVM among the three groups（P〈0.05）.There were also significant differences in left ventricular systolic function（such index as SV,FS,EF）and left ventricular diastolic function（E/A ratio）among the groups of（P〈0.05）.Conclusion Our findings indicate that the increasing glucose fluctuation may damage cardiac structure and the cardiac dysfunction in diabetes mellitus patients,and more attention should be paid to CGMS.