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| 大鼠心肌环核苷酸系统的增龄变化 | |
| 引用本文： | 陈国千 王霞文. 大鼠心肌环核苷酸系统的增龄变化[J]. 温州医学院学报, 1993, 23(2): 74-76 |
| 作者姓名： | 陈国千 王霞文 |
| 作者单位： | 温州医学院附属第一医院(陈国千)，重庆医科大学(王霞文) |
| 摘 要： | 测定不同月龄大鼠心室肌中cAMP、cGMP和钙调素(CaM)含量,及腺苷酸环化酶(AC)基础活性、AC肾上腺素激活活性、cAMP磷酸二酯酶(cAMP-PDE)活性。结果:cAMP、AC基础活性和AC肾上腺素激活活性随大鼠月龄增长而明显降低,cAMP/cGMP比值和CaM含量24月龄鼠明显低于10月龄鼠,cGMP含量10月龄鼠明显低于2月龄鼠,cAMP-PDE活性10月龄鼠明显高于2月龄鼠。提示心肌环核苷酸系统随大鼠月龄的增加而变化。 |
| 关 键 词： | 心肌 环一磷酸腺苷 环一磷酸鸟苷 |
CHANGES OF CYCLIC NUCLEOTIDE SYSTEM IN RAT MYOCARDIUM WITH AGING |
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| Chen Guoqian , Wang Xiawen.. CHANGES OF CYCLIC NUCLEOTIDE SYSTEM IN RAT MYOCARDIUM WITH AGING[J]. Journal of Wenzhou Medical College, 1993, 23(2): 74-76 | |
| Authors: | Chen Guoqian & Wang Xiawen. |
| Affiliation: | The First Affiliated Hospital of Wenzhou Medical College |
| Abstract: | The levels of cAMP, cGMP and calmodulin (CaM), and the activities of basal adenylate cyclase, epinephrine-stimulated adenylate cyclase and cAMP phosphodiesterase (cAMP- PDE ) in the myocardium of Wistar rats aged 2, 10 and 24 months were measured. The results showed that the level of cAMP and the activities of basal adenylate cyclase and epinephrine-stimulated adenylate cyclase were decreased significantly with aging. The ratio of cAMP/cGMP and the level of CaM were decreased in rats aged 24 months in com-parison with rats aged 10 months. In rats aged 10 months the level of cGMP was markedly lower and the activity of cAMP-PDE higher than in rata aged 2 months respectively. These results suggest that there were some changes of cyclic nucleotide system in myocardium with aging. |
| Keywords: | myocardiumj cyclic AMP} cyclic GMP |
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