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Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment |
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| Authors: | Kogure Takayuki Ueno Yoshiyuki Fukushima Koji Nagasaki Futoshi Inoue Jun Kakazu Eiji Matsuda Yasunori Kido Osamu Nakagome Yu Kimura Osamu Obara Noriyuki Wakui Yuta Iwasaki Takao Shimosegawa Tooru |
| Institution: | Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aobaku, Sendai City 980-8574, Japan |
| Abstract: | A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin,and her HCV-RNA became negative at wk 12,but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. |
| Keywords: | Autoimmune hepatitis Interferon Ribavirin Hepatitis C virus Anti-viral therapyA Acute liver failure |
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