马来酸桂哌齐特注射液治疗急性脑梗死血液流变学变化及疗效观察

目的 观察马来酸桂哌齐特注射液治疗急性脑梗死的临床疗效和对血液流变学的影响.方法 选择发病72 h内的脑梗死患者152例,按随机数字表法分为观察组(n=88)和对照组(n=64).观察组给予马来酸桂哌齐特注射液320mg.对照组给予复方丹参注射液20mL,均静脉滴注,1次/d,连用14d,观察两组临床疗效和血液流变学指标变化.结果 观察组治疗14d后的中国卒中量表(CSS)评分与对照组比较差异有统计学意义(P<0.05);观察组疗效、显效率(62.5%)优于对照组(35.9%),差异有统计学意义(P<0.05);观察组治疗后的各血液流变学指标下降程度较对照组明显,差异有统计学意义(P<0.05).结论 马米酸挂哌齐特注射液治疗急性脑梗死疗效显著,并能有效降低血液黏度.

Change of blood rheology of acute cerebral infarction patients after using Cinepazide Maleate Injection

Objective To study the effect of Cinepazide Maleate Injection on blood rheology of acute cerebral infarction patients. Methods 152 patients with cerebral infarction which attacked in 72 h after onset were separated into experimental group (n=88) and control group (n=64). 320 mg Cinepazide Maleate Injection was given to the experimental group and 20 mL Danshen Injection was given to control group, both by intravenous drip, once a day, for 14 d. The clinical efficacy and the changes of blood rheology were observed and compared in the 2 groups. Results The results of Chinese Stroke Scale (CSS) in the experimental group were significantly better than those in the control group (P<0.05), and the decrease in the parameters of blood rheology was much more obvious in the experimental group than in the control group (P<0.05) 2 weeks later. The excellent rate was 62.5% in the experimental group, which was higher than 35.9% in the control group significantly (P<0.05). Conclusion The Cinepazide Maleate Injection is effective in the treatment of acute cerebral infarction and can reduce the blood viscosity.