枣仁安神胶囊联合帕利哌酮治疗精神分裂症的临床研究

目的 观察丹蒌片对高脂喂养动脉粥样硬化模型ApoE^-/-小鼠的影响，从菌群失调诱发炎症角度探讨丹蒌片抗动脉粥样硬化的作用机制。方法 采用C57BL/6J野生型小鼠作为对照，高脂喂养ApoE^-/-小鼠24周后随机分为模型组、丹蒌片组，连续ig给药8周后取血测定血脂水平；ELISA法检测血清中脂多糖（LPS）水平；动脉大体油红O及主动脉窦HE染色观察斑块形成；粪便16 S rRNA扩增子测序检测肠道菌群；GC-MS法检测短链脂肪酸；实时荧光定量PCR法检测炎症因子肿瘤坏死因子-α（TNF-α）、细胞间黏附分子-1（ICAM-1）和白细胞介素-1β（IL-1β）mRNA的表达。结果 与对照组比较，模型组小鼠血脂水平升高，肠道菌群失调，有害菌增加，有益菌减少，血清LPS水平升高，主动脉周围炎症水平升高；与模型组比较，丹蒌片干预可明显降低小鼠总胆固醇（TC）、三酰甘油（TG）及低密度脂蛋白胆固醇（LDL-C）水平（P<0.01），有效减少斑块面积；调节肠道菌群，进而降低血清LPS及主动脉周围炎症因子TNF-α、ICAM-1和IL-1β水平（P<0.01）。结论 丹蒌片通过改善菌群结构，降低菌群失调诱发的炎症反应发挥抗动脉粥样硬化作用。

Clinical study of Zaoren Anshen Capsules combined with paliperidone in treatment of schizophrenia

Objective To study the efficacy of Zaoren Anshen Capsules combined with Paliperidone Extended-Release Tablets in treatment of schizophrenia. Methods Patients (80 cases) with schizophrenia in Tianjin Anding Hospital from September 2018 to September 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Paliperidone Extended-Release Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Zaoren Anshen Capsules on the basis of the control group, 5 grains/time, once daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and PSP score, PANSS score, GQOLI-74 score, the levels of IL-6 and NT-3 in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.00%) was significantly higher than that of the control group (77.50%) (P<0.05). After treatment, PSP score and GQOLI-74 score of two groups were significantly increased, but PANSS score of two groups was significantly decreased (P<0.05); And the PSP score and the GQOLI-74 score of the treatment group were significantly higher than those of the control group, but the PANSS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the serum levels of IL-6 in two groups were significantly decreased, but the serum levels of NT-3 in two groups were significantly increased (P<0.05); And the indexes in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Zaoren Anshen Capsules combined with Paliperidone Extended-Release Tablets has clinical curative effect in treatment of schizophrenia, can improve the clinical symptoms, and reduce the serum level of inflammatory factors.