Hb Las Palmas or alpha 2 beta 2(49)(CD8)Ser----Phe, a mildly unstable hemoglobin variant |
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| Authors: | J J Malcorra-Azpiazu M I Balda-Aguirre J C Diaz-Chico H Hu J B Wilson B B Webber F Kutlar A Kutlar T H Huisman |
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| Affiliation: | Departamento de Hematologia-Hemoterapia Hospital Materno-Infantil, Insalud, Canary Islands, Spain. |
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| Abstract: | A new hemoglobin variant with a Ser----Phe substitution at position beta 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45%, respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytosis. |
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