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| 胆囊癌p53、p73和p21WAF1蛋白的表达 | |
| 引用本文： | 莫瑞祥,胡虞乾,李西融,廖文胜,杨威. 胆囊癌p53、p73和p21WAF1蛋白的表达[J]. 江苏医药, 2008, 34(6): 552-554 |
| 作者姓名： | 莫瑞祥 胡虞乾 李西融 廖文胜 杨威 |
| 作者单位： | 广西壮族自治区第二人民医院普通外科,桂林,541002;广西壮族自治区第二人民医院病理科,桂林,541002 |
| 基金项目： | 广西桂林市科学研究与技术开发计划项目 |
| 摘 要： | 目的 探讨p53、p73和p21WAF1基因在胆囊癌中的表达.方法 应用免疫组化SP法检测48例胆囊癌、32例癌旁组织、20例正常胆囊组织p53、p73和p21WAF1蛋白的表达,分析p73和p21WAF1相互关系.结果 48例胆囊癌中,p53、p73和p21WAF1蛋白阳性表达率分别为56.2%、52.1%和43.8%,均高于癌旁组织和正常组织(P<0.01).胆囊癌中p73蛋白的表达与Nevin分期有关(P<0.05),p21WAF1蛋白的表达与淋巴结转移、Nevin分期有关(P<0.05).结论 p53、p73和p21WAF1基因在胆囊癌高表达,提示三者在胆囊癌发生发展中起重要作用.胆囊癌中p73与p21WAF1表达无相关性. |
| 关 键 词： | 胆囊肿瘤 p53蛋白 p73蛋白 p21WAF1蛋白 |
Expression of p53,p73 and p21~(WAF1) proteins in carcinoma of the gallbladder |
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| MO Ruixiang,HU Yuqian,LI Xirong,et al.. Expression of p53,p73 and p21~(WAF1) proteins in carcinoma of the gallbladder[J]. Jiangsu Medical Journal, 2008, 34(6): 552-554 | |
| Authors: | MO Ruixiang HU Yuqian LI Xirong et al. |
| Affiliation: | MO Ruixiang,HU Yuqian,LI Xirong,et al.Department of General Surgery,Second People's Hospital of Guangxi,Guilin 541002,CHINA |
| Abstract: | Objective To study the expression of p53,p73 and p21WAF1 proteins in carcinoma of the gallbladder.Methods Immunohistochemical method was used to detect the proteins of p53,p73 and p21 WAF1 in 48 patients with carcinoma of the gallbladder,32 cases with paratumor tissue and 20 normal gall bladde tissues.The relationship of p73 and p21 WAF1 expression was analyzed.Results The positive expression rates of p53,p73 and p21 WAF1 in 48 patients with carcinoma of the gallbladder were 56.2%,52.1% and 43.8%,respective... |
| Keywords: | Gallbladder neoplasms p53 Protein p73 Proteins p21WAF1Protein |
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