| 核糖体蛋白L6在K562/A02和K562细胞株中的表达差异 |
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| 引用本文： | 陈宏,姜浩,张志伟.核糖体蛋白L6在K562/A02和K562细胞株中的表达差异[J].南华大学学报(医学版),2006,34(4):519-521. |
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| 作者姓名： | 陈宏 姜浩 张志伟 |
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| 作者单位： | 1. 南华大学,第一附属医院,湖南,衡阳,421001
2. 南华大学,病理教研室 |
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| 摘 要： | 目的探讨核糖体蛋白L6（ribosomal proteinL6，RPL6）在急性髓细胞性白血病耐药细胞系K562／A02和敏感细胞系K562中的差异表达。方法分别从K562／A02和K562细胞中提取总RNA，以内参对照RT—PCR检测fuPL6基因表达。结果RPL6在飚62／A02细胞中的表达较K562高（P〈0．001）。结论在耐药细胞系K562／A02高表达RPL6可能与白血病耐药有关。
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| 关 键 词： | 核糖体蛋白L6 细胞株 |
| 文章编号： | 1672-7444(2006)04-0519-03 |
| 修稿时间： | 2006年4月29日 |
Different Expression of Ribosomal Protein L6 Between K562/A02 and K562 Cell Line |
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| CHEN Hong,JIANG Hao,ZHANG Zhi-wei.Different Expression of Ribosomal Protein L6 Between K562/A02 and K562 Cell Line[J].Journal of Nanhua University(Medical Edition),2006,34(4):519-521. |
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| Authors: | CHEN Hong JIANG Hao ZHANG Zhi-wei |
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| Abstract: | Objective To study the different expression of ribosomal protein L6(RPL6) between drug-resistant acute myeloblastic leukemia(AML) cell line K562/A02 and drug-sensitive cell line K562.Method Total RNA was extracted from K562/A02 and K562 cell,and RPL6 mRNA was detected by internal control RT-PCR.Result Internal control RT-PCR showed higher expression of RPL6 in K562/A02 than in K562(P<0.001).Conclusion High expression of RPL6 in drug-resistant K562/A02 cell has relationship with multi-drug resistance in AML. |
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| Keywords: | K562 K562/A02 |
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