食管鳞状细胞癌中基质金属蛋白酶-14和组织蛋白酶D的表达及对预后判断价值的研究

目的：检测食管鳞状细胞癌中基质金属蛋白酶-14（MMP-14）和组织蛋白酶-D（Cath-D）的表达特征,观察其在不同临床病理特征中的表达差别及相关性,以期为临床治疗提供理论支持。方法：以95例食管鳞状细胞癌作为观察组,以70例正常食管黏膜组织作为对照组,采用免疫组织化学方法检测2组中MMP-14和Cath-D的表达情况。结果：观察组中MMP-14和Cath-D表达的阳性率明显高于对照组,观察组中MMP-14和Cath-D表达的阳性率与肿瘤直径、分化程度、Ki67的表达密切相关。相关性分析显示观察组中MMP-14和Cath-D的表达呈正相关性。生存分析显示MMP-14和Cath-D的表达与预后相关。结论：食管癌组织中MMP-14和Cath-D高表达,对肿瘤的进展有促进作用;术后联合检测MMP-14和Cath-D的表达对判断食管鳞癌的预后有参考意义。

Expressions and its prognostic value research of MMP-14 and cathepsin-D in esophageal squamous cell carcinoma

AIM： To detect the expressions of MMP-14 and cathepsin D（Cath-D）,and investigate their significance on different clinical characteristic in esophageal squamous cell carcinonma,for providing help to clinical work.METHODS： The study included 95 cases of esophageal squamous cell carcinoma as observation group,70 cases of normal esophageal tissue as control group.We detected the expressions of MMP-14 and Cath-D by IHC methods in two groups.RESULTS：The positive rate of MMP-14 and Cath-D were higher in the observation group than in control group.The positive rate of MMP-14 and Cath-D were correlated with tumor diameter,differentiation and Ki67 expressions.There was positive correlationship between MMP-14 and Cath-D in esophageal squamous cell carcinoma.The expressions of MMP-14 and Cath-D were correlated with prognosis in esophageal squamous cell carcinoma.CONCLUSION： The high-expressions of MMP-14 and Cath-D may promote the occurrence and development in esophageal squamous cell carcinoma.The joint detection of MMP-14 and Cath-D may be helpful to predict the prognosis of esophageal squamous cell carcinoma.