Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children |
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| Authors: | T.‐C. Yao H.‐J. Tsai Y.‐L. Tu S.‐W. Chang M.‐C. Hua S.‐L. Liao M.‐H. Tsai C.‐Y. Chiu S.‐H. Lai K.‐W. Yeh J.‐L. Huang the PATCH study group |
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| Affiliation: | 1. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, , Taoyuan, Taiwan;2. Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, , Keelung, Taiwan;3. Division of Biostatistics and Bioinformatics, Institutes of Population Health Sciences, National Health Research Institutes, , Miaoli, Taiwan;4. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, , Chicago, IL, USA;5. Department of Genome Medicine, Kaohsiung University, , Kaohsiung, Taiwan;6. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, , Taoyuan, Taiwan;7. Clinical Informatics and Medical Statistics Research Center, Chang Gung University College of Medicine, , Taoyuan, Taiwan;8. Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, , Keelung, Taiwan;9. Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital, , Taoyuan, Taiwan |
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| Abstract: | This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose‐dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways. |
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| Keywords: | allergic sensitization Asian atopy children exhaled nitric oxide |
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