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Efficacy of a combined nanoparticulate/calcium hydroxide root canal medication on elimination of Enterococcus faecalis |
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| Authors: | Maryam Javidi DDS MS Farzaneh Afkhami DDS MS Mina Zarei DDS MS Kiarash Ghazvini PhD Omid Rajabi PharmD PhD |
| Institution: | 1. Department of Endodontics, Mashhad University of Medical Sciences, , Mashhad, Iran;2. Department of Endodontics, Tehran University of Medical Sciences, International Campus, , Tehran, Iran;3. Microbiology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, , Mashhad, Iran;4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, , Mashhad, Iran |
| Abstract: | The purpose of this study was to evaluate the efficacy of Ca(OH)2 with or without a silver nanoparticle suspension to eliminate Enterococcus faecalis from root canals. A total of 66 extracted human single‐rooted teeth contaminated with E. faecalis were treated with 10% Ca(OH)2 alone, Ca(OH)2 with nanosilver or sterile water (as a negative control). Samples were obtained with paper points and Gates‐Glidden burs at 1 and 7 days after root canal preparation and the number of colony‐forming units (CFU) was determined. The number of CFUs observed after dressing with Ca(OH)2 + nanosilver was significantly less than the number observed with Ca(OH)2 alone after 1 or 7 days (P < 0.001, P < 0.001). No differences in antimicrobial properties were observed between the two time points in the Ca(OH)2 + nanosilver group (P > 0.05). Higher antimicrobial efficacy was observed in the Ca(OH)2 group after 7 days than 1 day (P < 0.001). This study highlighted the potential advantage of using a mixture of Ca(OH)2 and nanosilver for intracanal medicament. |
| Keywords: | calcium hydroxide Enterococcus faecalis intracanal dressings silver nanoparticles |