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| 微囊藻毒素LR促肝癌过程中p53、p16基因mRNA表达研究 | |
| 作者单位： | Zhijian Hu1，2，Hua Chen2，Chunyan Pang2，Qiying Lin1 1 Institute of Virology，Fujian Agriculture and Forestry University，Fuzhou 350002，China 2 Public Health School，Fujian Medical University，Fuzhou 350004，China |
| 基金项目： | 福建省自然科学基金(项目编号：C0210011)the,Science,&.Technology,Program,for,the,Education,Department,of,Fujian,Province(项目编号：JA05256) |
| 摘 要： | Objective: To deeply explore the molecular mechanism of MCLR in the course of MCLR promoting liver tumor. Methods: We applied the two -stage- medium-term theory to set up the animal model, and biochemistry technique to evalu- ate the model, and then, used RT-PCR technique and image analysis to study the mRNA expression of the p53 and p16 in the course of promoting tumor. Results: (1) MCLR could enhance the positive reaction ratio of γ-Glutamyltransferase(GGT). (2) MCLR could increase the mRNA expression of p53, and had not effect on the mRNA expression of p53. Conclusion: (1) MC can promote liver tumor strongly. (2) The expression change of p53 may play an important role in the course of MCLR promoting liver tumor. |
| 关 键 词： | 肝癌 实验室 治疗 疗效 |
The expression of p53 and p16 in the course of microcystin-LR inducing of liver tumor |
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| Zhijian Hu,Hua Chen,Chunyan Pang,Qiying Lin. The expression of p53 and p16 in the course of microcystin-LR inducing of liver tumor[J]. The Chinese-German Journal of Clinical Oncology, 2008, 7(12): 690-693. DOI: 10.1007/s10330-008-0137-5 | |
| Authors: | Zhijian Hu Hua Chen Chunyan Pang Qiying Lin |
| Affiliation: | [1]Institute of Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, China [2]Public Health School, Fujian Medical University, Fuzhou 350004, China |
| Abstract: | Objective: To deeply explore the molecular mechanism of MCLR in the course of MCLR promoting liver tumor. Methods: We applied the two -stage- medium-term theory to set up the animal model, and biochemistry technique to evalu-ate the model, and then, used RT-PCR technique and image analysis to study the mRNA expression of the p53 and p16 in the course of promoting tumor. Results: (1) MCLR could enhance the positive reaction ratio of y-Glutamyltransferase(GGT). (2) MCLR could increase the mRNA expression of p53, and had not effect on the mRNA expression of p53. Conclusion: (1) MC can promote liver tumor strongly. (2) The expression change of p53 may play an important role in the course of MCLR promoting liver tumor. |
| Keywords: | microcystin GGT p53 p16 |
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