Natural interferon enhances expression of placental alkaline phosphatase in human seminoma xenograft |
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| Authors: | T Imao K Koshida H Konaka T Uchibayashi K Yokoyama K Hirano M Namiki |
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| Institution: | (1) Department of Urology, School of Medicine, Kanazawa University, 13-1, Takara-machi, Kanazawa, 920, Japan, JP;(2) Department of Nuclear Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan, JP;(3) Gifu Pharmaceutical University, Gifu, Japan, JP |
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| Abstract: | The purpose of this study was to investigate the effect of natural interferon (IFN) on the expression of placental alkaline
phosphatase (PLAP) in a human seminoma xenograft in severe combined immunodeficient mice. Mice were injected intramuscularly
with 3 × 105 U/mouse of IFN, twice a day, for five consecutive days. A significant increase in PLAP level of the xenografts followed IFN
treatment. A radiolabeled anti-PLAP monoclonal antibody (MAb) was intravenously injected on the first day of IFN administration
in order to determine if IFN has the potential to enhance the efficacy of an anti-PLAP MAb in the detection of seminoma. Enhanced
retention of the anti-PLAP MAb was observed at 7 and 11 days after MAb administration. Thus, IFN treatment appears to have
some effect on the efficacy of the anti-PLAP MAb in the detection of seminoma xenografts.
Received: 26 September 1997 / Accepted: 23 April 1998 |
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| Keywords: | Interferon Placental alkaline phosphatase Seminoma Immunolocalization |
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