Beta-Carotene Increases Lung Cancer Incidence in Cigarette Smokers |
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| Authors: | Luigi M. De Luca Ph.D Sharon A. Ross Ph.D. M.P.H |
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| Affiliation: | the Differentiation Control Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Building 37 Room 3A-17, National Cancer Institute, Bethesda, MD 20892–4255;the Cancer Prevention Fellowship Program, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892–4255. |
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| Abstract: | ![]()
Clinical trials were designed to validate the protective effect of β-carotene in populations of cigarette smokers at high risk for lung cancer development. Strikingly, an increase in lung cancer resulted following β-carotene supplementation in two separate studies in Finland and the United States. These trials were conducted without any evidence that β-carotene prevents lung cancer in animal models. |
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