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| 色素上皮细胞衍生因子:一种高效的新生血管抑制因子 | |
| 引用本文： | 金姬,关明,Hin-Fai Yam.色素上皮细胞衍生因子:一种高效的新生血管抑制因子[J].眼科新进展,2002,22(1):68-70. |
| 作者姓名： | 金姬 关明 Hin-Fai Yam |
| 作者单位： | 1. 321000,浙江省金华市中心医院眼科 2. 200040,上海市华山医院检验科 3. 香港中文大学眼科与视觉科学系 |
| 摘 要： | 色素上皮细胞衍生因子 (pigm ent epithelium- derived factor,PEDF)是最先在视网膜色素上皮细胞培养液中发现的细胞因子 ,属于丝氨酸蛋白酶抑制剂基因家族 ,但不具备抗蛋白酶活性。 PEDF有营养神经效果 ,保护神经元免受快速神经毒性侵害 (如谷氨酸毒性 )作用及“胶质细胞静息”特性。PEDF还能抑制血管内皮细胞移行 ,促进血管内皮细胞凋亡 ,正常角膜、玻璃体中PEDF含量较高 ,在低氧环境中降低。PEDF具有抗新生血管诱导因子的作用 ,目前 PEDF被视为最有效的细胞内新生血管抑制因子之一。可能对治疗神经元损伤和抑制血管生成特别有效。 |
| 关 键 词： | 神经营养因子 色素上皮细胞衍生因子 血管增生 |
| 文章编号： | 1003-5141(2002)01-0068-03 |
| 修稿时间： | 2001年6月18日 |
Pigment epithelium derived factor: a potent inhibitor of angiogenesis |
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| Hin-Fai Yam.Pigment epithelium derived factor: a potent inhibitor of angiogenesis[J].Recent Advances in Ophthalmology,2002,22(1):68-70. | |
| Authors: | Hin-Fai Yam |
| Abstract: | Pigment epithelium-derived factor (PEDF) , a neurotrophic agent first identified in conditioned medium from cultured human retinal pigment epithelial cells, induces neuronal differentiation. DNA sequence analysis shows PEDF belongs to the serine protease inhibitor(SERPIN) gene family, but PEDF does not seem to exhibit antiprotease activity. PEDF have "gliastatic" effect, along with neuron-survival character. PEDF appeared to inhibit angiogenesis by causing apoptosis of activated endothelial cells. The concentration of PEDF in the cornea and vitreous is sufficient to inhibit angiogenic stimulatory activity. PEDF is taken as one of the most effective antiangiogenic factors. It may prove to be a useful therapeutic for neuronal damage and inhibiting angiogenesis may be particularly effective. |
| Keywords: | neurotrophic factor pigment epithelium-derived factor angiogenesis |
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