合并SAHS对CKD患者并发CVD的影响

目的：：探讨慢性肾脏病(CKD)患者合并睡眠呼吸暂停低通气综合征(SAHS)对CKD患者心血管疾病(CVD)发病情况的影响。方法：调查92例CKD患者合并SAHS的情况，并分析CKD病情严重程度与SAHS患病率的关系；采用Logistic回归分析法分析CKD合并SAHS时对其CVD发病情况的影响。结果：92例CKD患者合并SAHS的患病率为83.70%(77/92)，以中枢性睡眠呼吸暂停(CSA)为主(49.35%，38/77)；终末期肾脏病患者合并SAHS的患病率明显高于非终末期肾脏病患者(P＜0.05)。Logistic回归分析显示，SAHS是CKD患者并发CVD的预测危险因子(OR=9.41，95% CI：2.16-41.03)；CKD合并SAHS患者CVD患病率明显高于CKD未合并SAHS者(P＜0.05)。结论：CKD患者容易合并SAHS，且以CSA为主；同时，SAHS可以增加CKD患者并发CVD的风险。

INFLUENCES OF SLEEP APNEA-HYPOPNEA SYNDROME ON CARDIOVASCULAR DISEASE INCIDENCE OF PATIENTS WITH CHRONIC KIDNEY DISEASE

Objective:To study the influences of chronic kidney disease (CKD) combined sleep apnea-hypopnea syndrome (SAHS) on cardiovascular disease (CAD) incidence of CDK patients.Methods:92 cases of CKD patients combined with SAHS were investigated, and analyzed the relationships between CKD severity and SAHS incidence, as well as inlfuences of CKD combined SAHS on CVD incidence by Logistic regression analysis.Results:The case rate of CKD combined SAHS was 83.70% in 92 CKD patients (77/92), and the type of SAHS was mainly central sleep apnea (49.35%, 38/77). The case rate of end-stage kidney disease combined SAHS was obviously higher than non end-stage kidney disease combined SAHS (P<0.05). Logistic regression analysis showed that SAHS was a risk factor for CKD patients complicated with CVD (OR=9.41, 95% CI: 2.16-41.03); The case rate of CVD in CKD patients combined with SAHS was obviously higher than CKD patients not combined with SAHS (P<0.05).Conclusions:The case rate of CKD combined SAHS is fairly higher, and the type of SAHS is mainly central sleep apnea. Meanwhile, SAHS can increase the risk of CKD patients with CVD.