健康成年人高通噪声掩蔽听性脑干反应研究

目的 研究健康成年人高通噪声掩蔽听性脑干反应(又称为耳蜗积水掩蔽分析程序,the cochlear hydrops analysis masking procedure,CHAMP)的特点,探讨CHAMP各参数在诊断膜迷路积水中的应用价值.方法 应用Bio-logic听性诱发电位系统对20名(40耳,其中男女各10名)耳科正常人记录由6种声信号所诱发的听性脑干反应(auditory brainstem response,ABR),包括:单独使用短声及截断点分别为8、4、2、1、0.5 kHz同侧高通滤过粉红噪声(high-pass masking pink noise)掩蔽下的短声信号.结果 高通滤过粉红噪声掩蔽下的短声所诱发的ABR V波潜伏期较短声ABR长,短声+8、4、2、1、0.5 kHz高通滤过粉红噪声的V波潜伏期延迟平均((x)±s,下同)分别为(0.30±0.18)、(0.97 ±0.43)、(1.65±0.64)、(3.21±0.56)、(4.66±0.37)ms.短声+0.5 kHz高通滤过粉红噪声诱发的ABR与短声ABR的复合振幅比为0.95 ±0.11.结论 对于膜迷路积水,CHAMP可能是一种很有前景的诊断方法,V波潜伏期延迟可作为判定CHAMP正常与否的标准,但复合振幅比的特异性有待进一步验证.

Abstract：

Objective To study the characteristic of the cochlear hydrops analysis masking procedure ( CHAMP) in normal adults, and to evaluate the diagnostic values of its parameters for logic auditory evoked potential system: clicks presented alone (unmasked condition) and clicks presented with ipsilateral pink noise high-pass filtered at 8 , 4, 2, 1, and 0. 5 kHz respectively. Results The wave V latency of ABR to the high-pass masking pink noise clicks were longer than ABR to clicks alone. The latency delays of wave V for clicks presented with ipsilateral pink noise high-pass filtered at 8 , 4, 2, 1, and 0.5 kHz compared to clicks alone were (0.30 ±0.18), (0.97 ±0.43), (1.65 ±0.64), (3.21 ±0.56),(4. 66 ± 0. 37 ) ms respectively. The complex amplitude ratio between ABR to click + 0. 5 kHz high-pass noise and click alone was 0.95 ±0.11. Conclusions CHAMP is a promising diagnostic method for membranous labyrinth hydrops, and the latency delay of wave V might be used as the normal criterion. The specificity of the complex amplitude ratio need furthur evaluation in clinical work.

Study of characteristic of the cochlear hydrops analysis masking procedure in normal adults

Objective To study the characteristic of the cochlear hydrops analysis masking procedure ( CHAMP) in normal adults, and to evaluate the diagnostic values of its parameters for logic auditory evoked potential system: clicks presented alone (unmasked condition) and clicks presented with ipsilateral pink noise high-pass filtered at 8 , 4, 2, 1, and 0. 5 kHz respectively. Results The wave V latency of ABR to the high-pass masking pink noise clicks were longer than ABR to clicks alone. The latency delays of wave V for clicks presented with ipsilateral pink noise high-pass filtered at 8 , 4, 2, 1, and 0.5 kHz compared to clicks alone were (0.30 ±0.18), (0.97 ±0.43), (1.65 ±0.64), (3.21 ±0.56),(4. 66 ± 0. 37 ) ms respectively. The complex amplitude ratio between ABR to click + 0. 5 kHz high-pass noise and click alone was 0.95 ±0.11. Conclusions CHAMP is a promising diagnostic method for membranous labyrinth hydrops, and the latency delay of wave V might be used as the normal criterion. The specificity of the complex amplitude ratio need furthur evaluation in clinical work.