专项整治前、后中山市人民医院烧伤科住院患者使用抗菌药物的合理性分析

目的：探讨开展抗菌药物专项整治活动对中山市人民医院（以下简称为“我院”）烧伤科住院患者使用抗菌药物情况的影响。方法：回顾性统计、分析我院烧伤科开展专项整治前、后出院患者的临床资料和抗菌药物使用情况。结果：经过专项整治，我院烧伤科住院患者抗菌药物使用率从整治前的100.00％下降至96.33％；抗菌药物销售金额占药品销售总金额的比例从整治前的61.78％下降至25.56％；抗菌药物使用强度（AUD）从整治前的162.35 DDDs／（100人·d）下降至55.78 DDDs／（100人·d）；抗菌药物的总DDDs由3335.55下降至1262.72；病原菌对常用抗菌药物的耐药率降低；单药使用率从76.27％上升至83.18％，但二联用药率和三联用药率的下降幅度不大，分别从16.10％下降至8.41％、从5.09％下降至4.68％。结论：专项整治对合理使用抗菌药物有明显的促进作用，但仍需加强对使用抗菌药物的监管。

Rationality of Antibiotic Use in Burn Patients of Zhongshan Municipal People s Hospital before and after Special Rectification

OBJECTIVE： To evaluate the effects of special rectification on rational use of antibiotics in our hospital. METHODS： The clinical data and the antibiotic use of the discharged burn patients before and after rectification（ Jul..Sept. period of 2010 versus Jul..Sept. period of 2012 ） were analyzed retrospectively. RESULTS：The rate（ mean value） of antibiotic use was reduced from 100.00% before rectification to 96.33% after rectification;the proportion of antibiotic cost in total drug cost decreased from 61.78% to 25.56%; AUD decreased from 162.35 DDDs/（100 persons·day） to 55.78 DDDs/（100 persons·day）; the total DDDs of antibacterials decreased from 3 335.55 to 1 262.72 . The resistance rates of pathogens to common antibiotics were reduced;the rate of single.drug use was up from 76.27% to 83.18% after rectification, but the rate of two.drug and three.drug use was down from 16.10% to 8.41% and that of three.drug was down from 5.09% to 4.68%. CONCLUSIONS： The special rectification activity promoted the antibiotic use and achieved primary outcome in burn department of our hospital;however, the rate of antibiotic use, AUD and the proportion of antibiotics in total in terms of drug cost failed to meet the ideal requirements;therefore, strengthened supervision on antibiotic use remains to be done.