| 维生素E对乙醇性肝损伤大鼠肝线粒体SOD和MDA的影响 |
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| 引用本文： | 金海燕,裴风郁.维生素E对乙醇性肝损伤大鼠肝线粒体SOD和MDA的影响[J].中西医结合肝病杂志,1997,7(4):221-223. |
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| 作者姓名： | 金海燕 裴风郁 |
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| 作者单位： | 延边大学医学院附属医院，延边大学医学院附属医院，延边大学医学院附属医院 延吉市 133000，延吉市 133000，延吉市 133000 |
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| 摘 要： | 目的:研究维生素E在乙醇性肝损伤肝组织亚细胞水平上的作用。方法:采用乙醇性肝损伤大鼠模型,测定乙醇灌胃及其VitE处理后肝线粒体SOD、MDA。结果:乙醇灌胃后肝线粒体SOD下降,而MDA上升;维生素E处理后SOD明显上升,MDA下降。结论:VitE可使乙醇性肝损伤大鼠肝线粒体SOD、MDA趋向正常,有抗氧化作用。
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| 关 键 词： | 维生素E 乙醇 脂质过氧化反应 肝损伤 |
Effect of Vitamin E on SOD and MDA in Hepatocyte Mitochondria of Rats Injured by Alcohol |
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| Jin Haiyan,Pei Fengyu,Piao Xixu The Affiliated Hospital of Medical College of Yanbian University.Effect of Vitamin E on SOD and MDA in Hepatocyte Mitochondria of Rats Injured by Alcohol[J].Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases,1997,7(4):221-223. |
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| Authors: | Jin Haiyan Pei Fengyu Piao Xixu The Affiliated Hospital of Medical College of Yanbian University |
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| Abstract: | Aim: At subcellular level to study the action of Vitamin E on hepatic tissue injured by alcohol. Method: Made rat's model injured by alcohol and measured the activities of SOD and Contents of MDA after giving ethanol and Vitamin E (only treatment group) by intragastric perfu-sion, respectively. Result: SOD activities reduced and MDA contents increased in hepatocyte mitochondria of experiment group, and after treatment with Vitamin E, SOD activities increased and MDA contents reduced. Conclusion: Vitamin E had antioxidation and could make SOD and MDA in hepatocyte mitochondria of rats injured by alcohol tend towards improvement. |
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| Keywords: | Vitamin E Ethanol Liver Injury Lipid Peroxidation |
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