蜂胶鱼油软胶囊对小鼠免疫功能的影响研究

目的观察蜂胶鱼油软胶囊对小鼠免疫功能的影响。方法设蜂胶鱼油软胶囊低、中、高3个剂量组（0．17g／kg、0．33g／kg、1．00g/kg，分别相当于人推荐量的5、10、30倍），另设阴性对照组（蒸馏水）和溶剂对照组（大豆油），经口灌胃给药30d，观察对刀豆素A（ConA）诱导脾淋巴细胞增殖功能、绵羊红细胞诱导的迟发型变态反应（DTH）、血清溶血素、抗体生成细胞、巨噬细胞吞噬鸡红细胞功能、NK细胞活性的影响。结果与对照组相比，中、高剂量组能显著增加小鼠溶血空斑数，并能显著提高小鼠腹腔巨噬细胞对鸡红细胞的吞噬率（P〈0．05）。结论蜂胶鱼油软胶囊具有增强非特异和体液免疫功能的作用。

Effects of propolis and fish oil soft capsule on the immune function of mice

Objective To observe the effects of propolis and fish oil soft capsule on the immune function of mice. Methods Mice were randomly divided into five groups：low,middle and high dose of propolis and fish oil soft capsule groups （0.17 g/kg,0.33 g/kg, 1.00 g/kg）,blank control group and solvent control group （soybean oil） and gavaged for 30 days.Then T lymphocyte transformations capacity induced by ConA,delayed type hypersensitivity （DTH） induced by SRBC, serum hemolysin, antibody forming-cells, macrophage phagocytic function of chicken red blood cells and NK activity were observed. Results High and middle dose groups could significantly improve the hemolytic plaque number of mice and increase the phagocytosis rate compared with the control group（P 〈 0.05）,but does not affect the other functions,their have no statistical significance. Conclusion Propolis and fish oil soft capsule could significantly improve the immune function of mice.