急性脑梗死患者治疗前后检测血清RBP、HCY的临床意义

目的 探讨急性脑梗死患者治疗前后血清RBP、HCY含量的变化及临床意义.方法 分别应用免疫比浊法、酶法对105例急性脑梗死患者进行血清RBP、HCY含量检测,并与51例健康对照组进行比较.结果 脑梗死组患者治疗前血清RBP、HCY含量显著高于健康对照组(P＜0.01)；经溶栓等措施治疗1个月后,与治疗前比较,差异有统计学意义(P＜0.05),与健康对照组比较差异也有统计学意义(P＜0.05).结论 血清RBP、HCY水平与急性脑梗死发生、发展与疗效密切相关,检测急性脑梗死患者治疗前后血清RBP、HCY水平的变化对监测治疗效果具有重要的临床意义.

Clinical significance of detection serum concentrations of RBP,HCY be- fore and after treatment in patients with acute cerebral infarction

Objective To study the clinical significance of detection of serum retinol-binding protein （RBP） and homocysteine （HCY） levels before and after treatment in patients with acute cerebral infarction. Methods Serum RBP,HCY levels were determined by immune turbidimetry and enzymatic assay in 105 patients with acute cerebral infarction and 51 normal people. Results Serum concentrations of RBP and HCY before treatment in patients with acute cerebral infarction were significantly higher than those of health control group （P 〈 0.01 ）. After one month＇s treatment, the serum concentrations of RBP and HCY were lower than before treatment in patients（P 〈 0.05） ,but still higher than those of health control group （P 〈 0.05）. Conclusion Detection of serum RBP and HCY before and after treatment is very important to monitor the treatment effect of patients with acute cerebral infarction.