自适应调强放疗对局部晚期宫颈癌的治疗效果

目的观察自适应调强放疗(ART)对局部晚期宫颈癌患者的治疗效果。方法将85例局部晚期宫颈癌患者随机分为对照组42例和观察组43例。2组患者均接受常规化疗,对照组联合采用逆向调强放疗(IMRT)外照射治疗,观察组联合ART治疗。治疗后,比较2组患者的临床疗效、危及器官剂量学指标水平和不良反应发生情况。结果治疗后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗8周末,观察组危及器官剂量学指标水平低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论ART应用于局部晚期宫颈癌患者中疗效显著,可减轻周围组织损伤,降低不良反应发生率,改善患者预后。

Effect of adaptive radiation therapy in treating locally advanced cervical cancer

Objective To observe the therapeutic effect of adaptive radiation therapy(ART)in patients with locally advanced cervical cancer.Methods A total of 85 patients with locally advanced cervical cancer were randomly divided into control group(n=42)and observation group(n=43).Patients in both groups received conventional chemotherapy,the control group was combined with external exposure of inverse intensity modulated radiation therapy(IMRT),and the observation group was combined with ART.After treatment,the clinical efficacy,the dosemetry level of organ at risk and the incidence of adverse reactions in two groups were compared.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);at the end of 8 weeks of treatment,the dosimetry level of organs at risk in the observation group was significantly lower than that in the control group(P<0.05);the incidence of adverse reactions in observation group was significantly lower than that in the control group(P<0.05).Conclusion ART in patients with locally advanced cervical cancer has a significant effect,which can relieve peripheral tissue damage,decrease the incidence of adverse reactions and improve the prognosis of patients.