血清HA、HAS2在骨肿瘤辅助诊断及疗效监测中的价值

目的 探究血清透明质酸(HA)及透明质酸合成酶(HAS)2在骨肿瘤辅助诊断中的应用价值.方法 检测35例骨肿瘤患者(骨肿瘤组)手术前、后以及40例骨感染性炎症患者(骨感染性炎症组)、60名体检健康者(正常对照组)的血清HA、HAS2水平和血清HAS2 mRNA相对表达量,采用受试者工作特征(ROC)曲线评估各项指标诊断...

Clinical value of combined detection of serum HA and HAS2 in diagnosis and therapeutic monitoring of bone tumors

Objective To investigate the application of serum hyaluronan(HA)and hyaluronan synthetase 2(HAS2)in bone tumor.Methods A total of 35 patients with bone tumor,40 patients with bone infection and 60 healthy subjects were enrolled.The expression levels of HA,HAS2 and HAS2 mRNA were determined.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficiency of each marker.Results The expression levels of HA,HAS2 and HAS2 mRNA in patients with bone tumor before and after surgery were significantly higher than those in healthy subjects(P<0.05).The expression levels of HAS2 and HAS2 mRNA in patients with bone tumor before and after surgery were significantly higher than those in patients with bone infection(P<0.05),but there was no significant difference in serum HA level between them(P>0.05).After bone tumors were removed,the expression levels of HA,HAS2 and HAS2 mRNA were significantly reduced(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of HA,Has2 and Has2 mRNA single detection and combined detection were 0.888,0.651,0.747 and 0.956,respectively,when healthy subjects were taken as control;and the AUC were 0.485,0.782,0.630 and 0.798,respectively,when bone infection group was taken as control.Conclusions The combined determination of HA,HAS2 and HAS2 mRNA plays a role in the auxiliary diagnosis and therapeutic monitoring of bone tumor.