Y染色体与男性不育关系的研究进展

Y染色体上含有对睾丸决定和睾丸分化过程起重要作用的基因和基因家族。男性不育原因多样,大量研究表明Y染色体微缺失与男性不育的关系密切。与X染色体相比,由于Y染色体大部分不参与性染色体的重组,使它无论在大小还是基因数量上都出现了退化,未来的男性或许会面临生存的问题。现就Y染色体与男性不育、未来男性的命运进行综述。

Advances in Researches on the Relationship of Y Chromosome with Male Infertility

The Y chromosome contains genes and gene families that play critical roles in the process of testis determination and differentiation. Male infertility can be induced by many factors, and extensive studies have strongly indicated that Y chromosome microdeletions are closely related to male reproductive dysfunction. Because most of the Y chromosome does not participate in sexual recombination, it has degenerated both in size and gene content, in comparison with the X chromosome. Consequently males may be faced with survival problems in the future. This article reviews the role of the Y chromosome in male infertility and the fate of the male in the future.