成年男性血清生殖激素水平与精液量以及精子密度的关系

目的:探索普通成年男性血清生殖激素水平与精液量以及精子密度的关系。方法:资料来源于对5个研究现场(河北省石家庄市、山西省太原市、贵州省贵阳市、浙江省杭州市及山东省青岛市)的普通成年男性的横断面调查。同时收集研究对象的血样和精液样本,分析黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)以及雌二醇(E2)与精液量、精子密度之间的关系。结果:共招收研究对象978名,通过相关分析及方差分析表明,高水平T对象的精子密度较低;高水平E2对象精液量较少。Logistic回归分析发现,高水平T发生低精子密度的危险性大,低水平的LH发生低精子密度的危险性小。结论:普通成年男性血清中生殖激素水平与精液数量指标有关,但表现出的某些关联性用已知的下丘脑-垂体-睾丸轴调节机制尚无法完全解释。

Relationships between Serum Reproductive Hormones and Sperm Density as well as Semen Volume in Chinese Adults

Objective:To investigate the relationships between serum reproductive hormones and sperm density and semen volume in ordinary adult men.Methods: This study was a cross-sectional epidemiological survey,combined with laboratory measures of hormonal profiles(FSH,LH,T,and E2) and semen.The data came from the ordinary volunteers in 5 selected cities of China(Shi Jiazhuang,Tai Yuan,Hang Zhou and Qing Dao).Results: A total of 978 eligible subjects were recruited,the liner correlation analysis and variance analysis showed that sperm density was significantly lower in high T group compared with low groups,and semen volume in high E2 group was less than low groups.The logistic regression analysis showed that high T group had a higher risk for low semen density and low FSH had a lower risk.Conclusion: Semen measures in ordinary adult men were related to serum reproductive hormones,but well-known hypothalamic-pituitary-testicular axis could not fully explain their relationships.