| 紫杉类药物在乳腺癌治疗中的耐药机制 |
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| 引用本文： | 严婷婷,林燕苹. 紫杉类药物在乳腺癌治疗中的耐药机制[J]. 国际肿瘤学杂志, 2009, 36(10). DOI: 10.3760/cma.j.issn.1673-422X.2009.10.020 |
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| 作者姓名： | 严婷婷 林燕苹 |
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| 作者单位： | 复旦大学附属肿瘤医院乳腺外科,复旦大学上海医学院肿瘤学系,上海,200032 |
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| 摘 要： | 目前研究提示紫杉类耐药可能与多药耐药相关蛋白(MRP)表达增高、Ⅲβ-微管过表达、微管相关蛋白tau的过表达有关,而与HER2的表达成负相关.针对这些耐药靶点可逆转或者延缓紫杉类药物耐药的发生,为临床上更好地使用紫杉类药物提供一定参考.
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| 关 键 词： | 乳腺肿瘤 抗肿瘤药 植物 抗药性 肿瘤 |
The mechanisms of taxanes resistance in the treatment of breast cancer |
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| Abstract: | Recent studies show that taxanes resistances may be positively associated with overexpression of MRP protein,the change of β-microtuble,thus negatively associated with the expression of HER-2.The therapies which are specific to these targets will reverse or postpone the occurrence of drug resistance and provide more evidences on the better use of taxanes in clinic. |
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| Keywords: | Breast neoplasms Antineoplastic agents phytogenic Drug resistance neoplasm |
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